Manufacture of complex heart tissues: technological advancements and future directions

Yihan Zhang; Yihan Zhang

doi:10.3934/bioeng.2021008

AIMS Bioengineering

2021, Volume 8, Issue 1: 73-92. doi: 10.3934/bioeng.2021008

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Review Topical Sections

Manufacture of complex heart tissues: technological advancements and future directions

Yihan Zhang ^{1,2
,
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1.
School of Food Science and Engineering, Jiangnan University, Wuxi 214122, Jiangsu, China
2.
School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China

Received: 02 December 2020 Accepted: 05 January 2021 Published: 20 January 2021

The latest technological advances in stem cell biology and mechanical engineering provide new opportunities for cardiac tissue engineering, enabling the production of highly efficient differentiated cells and the manufacture of high-resolution complex cardiac tissues. In this review, we summarize the progress of stem cell technology in 3D bioprinting of heart tissue and the latest technological breakthroughs. The main topics discussed include somatic cell reprogramming, differentiation of induced pluripotent stem cells (iPSCs), 3D bioprinting strategies, bioinks, and in vitro vascularization methods. The objective of this review is to explore the possibility of interdisciplinary research to solve the existing challenges in tissue engineering by summarizing the existing work and progress and pointing their current limitations.
- iPSCs,
- 3D bioprinting,
- bioink,
- cardiac tissue engineering,
- differentiation,
- vascularization,
- cell sheet
Citation: Yihan Zhang. Manufacture of complex heart tissues: technological advancements and future directions[J]. AIMS Bioengineering, 2021, 8(1): 73-92. doi: 10.3934/bioeng.2021008

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Abstract

The latest technological advances in stem cell biology and mechanical engineering provide new opportunities for cardiac tissue engineering, enabling the production of highly efficient differentiated cells and the manufacture of high-resolution complex cardiac tissues. In this review, we summarize the progress of stem cell technology in 3D bioprinting of heart tissue and the latest technological breakthroughs. The main topics discussed include somatic cell reprogramming, differentiation of induced pluripotent stem cells (iPSCs), 3D bioprinting strategies, bioinks, and in vitro vascularization methods. The objective of this review is to explore the possibility of interdisciplinary research to solve the existing challenges in tissue engineering by summarizing the existing work and progress and pointing their current limitations.

Acknowledgments

The author thanks Merlene Mo for providing assistance in drawing illustrations.

Conflict of interest

The author declare no conflict of interest.

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