Effect of nanometer scale surface roughness of titanium for osteoblast function

Satoshi Migita; Kunitaka Araki; Satoshi Migita; Kunitaka Araki

doi:10.3934/bioeng.2017.1.162

AIMS Bioengineering

2017, Volume 4, Issue 1: 162-170. doi: 10.3934/bioeng.2017.1.162

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Effect of nanometer scale surface roughness of titanium for osteoblast function

Satoshi Migita ^,,
Kunitaka Araki

Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan

Received: 13 January 2017 Accepted: 21 February 2017 Published: 28 February 2017

Surface roughness is an important property for metallic materials used in medical implants or other devices. The present study investigated the effects of surface roughness on cellular function, namely cell attachment, proliferation, and differentiation potential. Titanium (Ti) discs, with a hundred nanometer- or nanometer-scale surface roughness (rough and smooth Ti surface, respectively) were prepared by polishing with silicon carbide paper. MC3T3-E1 mouse osteoblast-like cells were cultured on the discs, and their attachment, spreading area, proliferation, and calcification were analyzed. Cells cultured on rough Ti discs showed reduced attachment, proliferation, and calcification ability suggesting that the surface inhibited osteoblast function. The findings can provide a basis for improving the biocompatibility of medical devices.
- titanium,
- roughness,
- osteoblast,
- cell attachment,
- biomaterial
Citation: Satoshi Migita, Kunitaka Araki. Effect of nanometer scale surface roughness of titanium for osteoblast function[J]. AIMS Bioengineering, 2017, 4(1): 162-170. doi: 10.3934/bioeng.2017.1.162

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Abstract

Surface roughness is an important property for metallic materials used in medical implants or other devices. The present study investigated the effects of surface roughness on cellular function, namely cell attachment, proliferation, and differentiation potential. Titanium (Ti) discs, with a hundred nanometer- or nanometer-scale surface roughness (rough and smooth Ti surface, respectively) were prepared by polishing with silicon carbide paper. MC3T3-E1 mouse osteoblast-like cells were cultured on the discs, and their attachment, spreading area, proliferation, and calcification were analyzed. Cells cultured on rough Ti discs showed reduced attachment, proliferation, and calcification ability suggesting that the surface inhibited osteoblast function. The findings can provide a basis for improving the biocompatibility of medical devices.

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