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AIMS Environmental Science

2015, Volume 2, Issue 1: 1-20. doi: 10.3934/environsci.2015.1.1
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Findings on prenatal, lactational and later childhood exposure to dioxins and dioxin-like compounds: a review of the Amsterdam-Zaandam cohort 1987-2005

  • 1.
    Department of Paediatrics and Neonatology, Westfriesgasthuis, Maelsonstraat 3, 1624 NP Hoorn, The Netherlands;
  • 2.
    University Hospital Aachen, Department of Dermatology, 52074 Aachen, Germany;
  • 3.
    Ecobaby Foundation, Hollandstraat 6, 3634 AT Loenersloot, The Netherlands;
  • 4.
    IBED/ESS, University of Amsterdam, Sciencepark 904, 1098 XH Amsterdam, The Netherlands;
  • 5.
    Department of Paediatrics, Emma Children's Hospital Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
  • Received: 30 October 2014 Accepted: 20 January 2015 Published: 01 February 2015

  • The Amsterdam-Zaandam cohort has been studied intermittently since 1987. The cohort was selected for optimal pregnancy and birth, in whom prenatal, lactational and more recently current dioxin exposures were measured. In the perinatal period and during the years thereafter, effects on various organ systems have been documented: thyroid, metabolism, immunity, haematology, motor development, brain development, lung function and puberty. We present a review of the endpoints studied, from the perinatal period into adolescence.

    Citation: Gavin W. ten Tusscher, Marike M. Leijs, Kees Olie, Adri Ilsen, Tom Vulsma, Janna G. Koppe. Findings on prenatal, lactational and later childhood exposure to dioxins and dioxin-like compounds: a review of the Amsterdam-Zaandam cohort 1987-2005[J]. AIMS Environmental Science, 2015, 2(1): 1-20. doi: 10.3934/environsci.2015.1.1

    Related Papers:

  • The Amsterdam-Zaandam cohort has been studied intermittently since 1987. The cohort was selected for optimal pregnancy and birth, in whom prenatal, lactational and more recently current dioxin exposures were measured. In the perinatal period and during the years thereafter, effects on various organ systems have been documented: thyroid, metabolism, immunity, haematology, motor development, brain development, lung function and puberty. We present a review of the endpoints studied, from the perinatal period into adolescence.


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    [1] Koppe JG, Pluim HJ, Olie K. (1989) Breastmilk, PCB's, Dioxins and Vitamin K Deficiency. J Roy Soc Med 82: 416-420.
    [2] Touwen BC, Huisjes HJ, Jurgens-van der Zee AD, et al. (1980) Obstetrical condition and neonatal neurological morbidity. An analysis with the help of the optimality concept. Early Hum Dev 4: 207-228.
    [3] Pluim HJ, Slot PC, Olie K, et al. (1992) Diurnal variations in concentrations of PCDDs and PCDFs in human milk. Chemosphere 25: 307-311. doi: 10.1016/0045-6535(92)90547-5
    [4] Pluim HJ, Wever J, Koppe JG, et al. (1993) Intake and faecal excretion of chlorinated dioxins and dibenzofurans in breastfed infants at different ages. Chemosphere 26: 1947-1952. doi: 10.1016/0045-6535(93)90021-V
    [5] Pluim HJ, Kramer I, van der Slikke JW, et al. (1993) Levels of PCDDs and PCDFs in human milk: dependence on several parameters and dietary habits. Chemosphere 26: 1889-1895. doi: 10.1016/0045-6535(93)90082-G
    [6] Pluim HJ, Boersma ER, Kramer I, et al. (1994) Influence of short-term dietary measures on dioxin concentrations in human milk. Environ Health Perspect 102: 968-971. doi: 10.1289/ehp.94102968
    [7] Pluim H, Koppe JG, Olie K, et al. (1992) Effects of dioxins on thyroid function in newborn babies. Lancet 339: 1303.
    [8] Pluim HJ, de Vijlder JJ, Olie K, et al. (1993) Effects of pre- and postnatal exposure to chlorinated dioxins and furans on human neonatal thyroid hormone concentrations. Environ Health Perspect 101: 504-508. doi: 10.1289/ehp.93101504
    [9] Koopman-Esseboom C, Morse DC, Weisglas-Kuperus N, et al. (1994) Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants. Pediatr Res 36: 468-473. doi: 10.1203/00006450-199410000-00009
    [10] Pluim HJ, van der Goot M, Olie K, et al. (1996) Missing effects of background dioxin exposure on development of breastfed infants in the first half year of life. Chemosphere 33:1307-1315. doi: 10.1016/0045-6535(96)00268-8
    [11] Pluim HJ, Koppe JG, Olie K, et al. (1994) Clinical laboratory manifestations of exposure to background levels of dioxins in the perinatal period. Acta Paediatr 83: 583-587.
    [12] Pluim HJ, van der Slikke JW, Olie K, et al. (1994) Dioxins and vit K status of the newborn. J Environ Sci Heal A 29: 793-802.
    [13] Weisglas-Kuperus N, Sas TCJ, Koopman-Esseboom C, et al. (1995) Ímmunologic effects of background prenatal and postnatal exposure to dioxins and polychlorinated biphenyls in Dutch Infants. Pediatr Res 38: 404-410. doi: 10.1203/00006450-199509000-00022
    [14] ten Tusscher GW, Steerenberg PA, van Loveren H, et al. (2003) Persistent Hematologic and Immunologic disturbances in 8-year-Old Dutch children Associated with Perinatal Dioxin Exposure. Environ Health Perspect 111: 1519-1523. doi: 10.1289/ehp.5715
    [15] Leijs MM, Koppe JG, Olie K, et al. (2009) Effects of dioxins, PCBs and PBDEs on immunology and haematology in adolescents. Environ Sci Technol 43: 7946-7951. doi: 10.1021/es901480f
    [16] Ackerman MF, Gasiewicz TA, Lamm KR, et al. (1989) Selective inhibition of polymorphonuclear neutrophil activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 101: 470-480. doi: 10.1016/0041-008X(89)90195-6
    [17] Watanabe S, Kitamura K, Otaki M, et al. (2001) Health effects of chronic exposure to polychlorinated dibenzo-p-dioxins, dibenzofurans and co-planar PCBs in Japan. Organohalogen Compounds 53: 136-140.
    [18] Geusau A, Abraham K, Geissler K, et al. (2001) Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: clinical and laboratory effects. Environ Health Perspect 109: 865-869. doi: 10.1289/ehp.01109865
    [19] McHale CM, Zhang L, Hubbard AE, et al. (2007) Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects. Toxicology 229: 101-113. doi: 10.1016/j.tox.2006.10.004
    [20] McKinney JD, Fawkes J, Jordan S, et al. (1985) 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) as a potent and persistent thyroxine agonist; A mechanistic model for toxicity based on molecular reactivity. Environ Health Perspect 61: 41-53. doi: 10.1289/ehp.856141
    [21] Rogan WJ, Gladen BC, Hung KL, et al. (1988) Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science 241: 334-336. doi: 10.1126/science.3133768
    [22] Ilsen A, Briet JM, Koppe JG, et al. (1996) Signs of enhanced neuromotor maturation in children due to perinatal load with background levels of dioxins. Follow-up until age 2 years and 7 months. Chemosphere 33: 1317-1326.
    [23] Schellart NAM, Reits D (2008) Influences of perinatal dioxin load to visual motion and oddball stimuli examined with an EEG and MEG analysis. Clin Neurophysiol 119: 1486-1495. doi: 10.1016/j.clinph.2008.03.002
    [24] ten Tusscher GW, Leijs MM, de Boer LCC, et al. (2014) Neurodevelopmental retardation, as assessed clinically and with magnetoencephalography and electroencephalography,associated with perinatal dioxin exposure. Sci Total Environ 491-492: 235-239. doi: 10.1016/j.scitotenv.2014.02.100
    [25] Koopman-Esseboom C, Huisman M, Weisglas-Kuperus N, et al. (1994) Dioxin and PCB Levels in Blood and Human Milk in relation to living areas in the Netherlands. Chemosphere 29: 2327-2338. doi: 10.1016/0045-6535(94)90401-4
    [26] Waalkes MP, Qu W, Tokar EJ, et al. (2014) Lung tumors induced by "whole life" inorganic arsenic exposure at human-relevant doses. Arch Toxicol 88: 1619-1629. doi: 10.1007/s00204-014-1305-8
    [27] Laporte JR. (1977) Effects of dioxin exposure. Lancet 1: 1049-1050.
    [28] Pluim HJ, van der Slikke JW, Olie K, et al. (1994) Dioxins and vit K status of the newborn. J Env Sci Health A29: 793-802.
    [29] ten Tusscher GW, Guchelaar HJ, Koch JP, et al. (2008) Perinatal dioxin exposure,cytochrome P-450 activity, liver functions and thyroid hormones at follow-up after 7-12 years. Chemosphere 70: 1865-1872. doi: 10.1016/j.chemosphere.2007.08.001
    [30] ten Tusscher GW, de Weerdt J, Roos CM, et al. (2001) Decreased lung function associated with perinatal exposure to Dutch background levels of dioxins. Acta Paediatr 90: 1292-1298. doi: 10.1111/j.1651-2227.2001.tb01578.x
    [31] Forouhandeh-Gever M, ten Tusscher GW, Westra M, et al. (1999) Does perinatal exposure to background levels of dioxins have a lasting effect on dentition?. Organohalogen Compounds 44: 279-281.
    [32] Alaluusua S, Lukinmaa PL, Torppa J, et al. (1999) Developing teeth as biomarker of dioxin exposure. Lancet 353: 206.
    [33] ten Tusscher GW, Stam GA, Koppe JG (2000) Open chemical combustions resulting in a local increased incidence of orofacial clefts. Chemosphere 40: 1263-1270. doi: 10.1016/S0045-6535(99)00378-1
    [34] Leijs MM, Teunenbroek TV, Olie K, et al. (2008) Assessment of current serum levels of PCDD/Fs, dl-PCBs and PBDEs in a Dutch cohort with known perinatal PCDD/F exposure. Chemosphere 73: 176-181. doi: 10.1016/j.chemosphere.2008.05.056
    [35] Fenton SE, Hamm JT, Birnbaum LS, et al. (2002) Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Sci 67: 63-74. doi: 10.1093/toxsci/67.1.63
    [36] Leijs MM, Koppe JG, Olie K, et al. (2008) Delayed initiation of breast development in girls with higher prenatal dioxin exposure; a longitudinal cohort study. Chemosphere 73: 999-1004. doi: 10.1016/j.chemosphere.2008.05.053
    [37] den Hond E, Roels HA, Hoppenbrouwers K, et al. (2002) Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek's hypothesis revisited. Environ Health Perspect 110: 771-776. doi: 10.1289/ehp.02110771
    [38] Dhooge W, den Hond E, Koppen G, et al. (2010) Internal exposure to pollutants and body size in Flemish adolescents and adults: associations and dose-response relationships. Environ Int 36: 330-337. doi: 10.1016/j.envint.2010.01.005
    [39] Luebke RW, Dewitt JC, Germolec DR, et al. (2012) Immunomodulation by persistent organic pollutants, in: Schecter A, Dioxins and Health, 3 eds. Hoboken, New Jersey: Wiley, 171-192.
    [40] Li R, Yang Q, Qui X, et al. (2013) Reactive Oxygen Species Alteration of Immune Cells in Local Residents at an Electronic Waste Recycling Site in Northern China. Environ Sci Technol 47: 3344-3352.
    [41] Weisglas-Kuperus N, Patandin S, Berbers GA, et al. (2000) Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ Health Perspect 108: 1203-1207. doi: 10.1289/ehp.001081203
    [42] Leijs MM, ten Tusscher GW, Olie K, et al. (2012) Thyroid Hormone metabolism and environmental chemical exposure. Environ Health 11: S10.
    [43] Leijs MM (2010) Toxic Effects of Dioxins and PBDEs in Adolescents. University of Amsterdam, PhD thesis.
    [44] Novelli M, Piaggi S, De TV (2005) 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced impairment of glucose-stimulated insulin secretion in isolated rat pancreatic islets. Toxicol Lett 156: 307-314. doi: 10.1016/j.toxlet.2004.12.004
    [45] Piaggi S, Novelli M, Martino L, et al. (2007) Cell death and Impairment of glucose-stimulated insulin secretion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the beta-cell line INS-1E. Toxicol Appl Pharm 220: 333-340. doi: 10.1016/j.taap.2007.01.017
    [46] Lee DH, Lee IK, Song K, et al. (2006) A strong Dose-Response Relation Between Serum Concentrations of Persistent Organic Pollutants and Diabetes. Diabetes Care 29: 1638-1644. doi: 10.2337/dc06-0543
    [47] Avdalovic M, Putney L, Finkbeiner W, et al. (2009) In utero and postnatal exposure to environmental tobacco smoke (ETS) alters alveolar and respiratory bronchioli growth and development in infant monkeys. Toxicol Pathol 37: 256-263. doi: 10.1177/0192623308330788
    [48] Beech DJ, Sibbons PD, Howard CV, et al. (2000) Terminal bronchiolar duct ending number does not increase post-natally in normal infants. Early Hum Dev 59: 193-200. doi: 10.1016/S0378-3782(00)00095-5
    [49] Beech DJ, Howard CV, Reed MG, et al. (2000) Unbiased and efficient estimation of the total number of terminal bronchiolar duct endings in lung:a modified physical disector. J Microsc 197: 36-45. doi: 10.1046/j.1365-2818.2000.00636.x
    [50] Guo YL (1999) Human health effects from PCBs and dioxin-like chemicals in the rice-oil poisonings as compared with other exposure episodes. Organohalogen Compounds 42: 241-242.
    [51] ten Tusscher GW, Leijs MM, Koppe JG, et al. (2010) Environmental contaminants and lung function - the missing link? in: Leijs MM. Toxic Effects of Dioxins, PCBs and PBDE's in Adolescents, Amsterdam: University of Amsterdam; 127-134.
    [52] Pluim HJ, Koppe JG, Olie K, et al. (1994) Clinical laboratory manifestations of exposure to background levels of dioxins in the perinatal period. Acta Paediatr 83: 583-587.
    [53] Ilsen A, Briet JM, Koppe JG, et al. (1996) Signs of enhanced neuromotor maturation in children due to perinatal load with background levels of dioxins. Follow-up until age 2 years and 7 months. Chemosphere 33: 1317-1326.
    [54] Koppe JG, Pluim HJ, Olie K, et al. (1991) Breast milk, dioxins and the possible effects on the health of newborn infants. Sci Total Environ 106: 33-41. doi: 10.1016/0048-9697(91)90018-A
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