Special Issue: Methodological trends in structural biology 2021
Guest Editors
Prof. Giuseppe Zanotti
Department of Biomedical Sciences, University of Padova Italy
Email: giuseppe.zanotti@unipd.it
Dr. Eaazhisai Kandiah
ESRF, Grenoble, France
Email: eaazhisai.kandiah@esrf.fr
Dr. Alessandro Grinzato
Department of Biomedical Sciences, University of Padova Italy
Email: alessandro.grinzato@unipd.it
Manuscript Topics
A sort of revolution has taken place in structural biology in the last few years: the coming of age of the cryo-Electron Microscopy technique, which now allows the determination of macromolecular structures up to atomic resolution, has drastically changed the panorama. For more than half a century X-ray diffraction has been the only experimental technique capable of showing the atomic details of biological macromolecules, to which NMR has been added in the 1980s. CryoEM has now become a strong actor in the field, in particular for large macromolecular aggregates that are hard or impossible to obtain in crystal form, and the three techniques appear now as firmly complementary. The main goal of this special issue is not only to present the most recent methodological advances in the various structural techniques, but also to discuss the future directions these techniques will take, in which direction they will develop in order to foresee how the structural biology landscape will look like over the next ten years.
Submitted papers should not have been previously published nor be currently under consideration for publication elsewhere. All manuscripts will be peer-reviewed before their acceptance for publication.
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