Manuscript Topics

MultiCellular Tumor Spheroids (MCTS) mimic the in vivo observations. It is now widely accepted that they accurately reproduce the 3D architecture of solid tumors, filling the gap between monolayer cultured cells and animal models. Their ability to evaluate new anticancer strategies is increasingly recognized. In particular, MCTS are complex cell aggregates which can reproduce the mechanical behaviors of microtumors. MCTS thus provide an interesting tool to investigate new cancer therapeutical strategies as drugs and nanodrugs uptake and its effect on the tumor growth, effect of electric field on the growth and the uptake of molecules…It is also worth noting that microtissues are in vitro biological models that enable to study the influence of the environment on the tumor behavior (for instance the effect mechanical constraints on the growth, the fusion of spheroids …). Another track investigated by this special issue is linked to the impact of the respiration/fermentation on the organism development. For such investigation Eukaryotic cells are too complex (especially to knock-down on way of energy production) but yeasts provide interesting alternatives to investigate the transitions between multi- and uni-cellularity phenotypes through for instance the change of metabolism.

The aim of this special issue is to present the recent achievements on microtissues in cancer, from biological, bioengineering, numerical and mathematical points of view. The topics to be covered by the special issue include, but are not restricted to, the following:

1. Numerical models of spheroids and microtissues.
2. Anti-cancer (nano)-drugs designing based on spheroids: experiments and model.
3. New biophysical therapeutical strategies based on physical means (such as electroporation, radiation therapy…)  from spheroids experiments: data, and models.
4. Microtissue and organoids mechanical properties: fusion, growth under mechanical constraints…
5. Microvasculature models and experiments.
6. Yeast experiments and models on multicelluarity.

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