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AIMS Molecular Science

2016, Volume 3, Issue 2: 269-279. doi: 10.3934/molsci.2016.2.269
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Oxidative stress and CCN1 protein in human skin connective tissue aging

  • Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
  • Received: 10 March 2016 Accepted: 29 May 2016 Published: 25 January 2016

  • Reactive oxygen species (ROS) is an important pathogenic factor involved in human aging. Human skin is a primary target of oxidative stress from ROS generated from both extrinsic and intrinsic sources, like ultraviolet irradiation (UV) and endogenous oxidative metabolism. Oxidative stress causes the alterations of collagen-rich extracellular matrix (ECM), the hallmark of skin connective tissue aging. Age-related alteration of dermal collagenous ECM impairs skin structural integrity and creates a tissue microenvironment that promotes age-related skin diseases, such as poor wound healing and skin cancer. Here, we review recent advances in our understanding of oxidative stress and CCN1 protein (first member of CCN family proteins), a critical mediator of oxidative stress-induced skin connective tissue aging.

    Citation: Zhaoping Qin, Patrick Robichaud, Taihao Quan. Oxidative stress and CCN1 protein in human skin connective tissue aging[J]. AIMS Molecular Science, 2016, 3(2): 269-279. doi: 10.3934/molsci.2016.2.269

    Related Papers:

  • Reactive oxygen species (ROS) is an important pathogenic factor involved in human aging. Human skin is a primary target of oxidative stress from ROS generated from both extrinsic and intrinsic sources, like ultraviolet irradiation (UV) and endogenous oxidative metabolism. Oxidative stress causes the alterations of collagen-rich extracellular matrix (ECM), the hallmark of skin connective tissue aging. Age-related alteration of dermal collagenous ECM impairs skin structural integrity and creates a tissue microenvironment that promotes age-related skin diseases, such as poor wound healing and skin cancer. Here, we review recent advances in our understanding of oxidative stress and CCN1 protein (first member of CCN family proteins), a critical mediator of oxidative stress-induced skin connective tissue aging.


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