Nano bio-MOFs: Showing drugs storage property among their multifunctional properties

Tabinda Sattar; Muhammad Athar; Tabinda Sattar; Muhammad Athar

doi:10.3934/matersci.2018.3.508

AIMS Materials Science

2018, Volume 5, Issue 3: 508-518. doi: 10.3934/matersci.2018.3.508

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Nano bio-MOFs: Showing drugs storage property among their multifunctional properties

Tabinda Sattar ,
Muhammad Athar ^,

Institute of Chemical Sciences, BZU, Multan, Pakistan

Received: 24 October 2017 Accepted: 22 January 2018 Published: 25 May 2018

Nano bio-MOF compounds 6–8 (cobalt argeninate, cobalt asparaginate, and cobalt glutaminate) have been evaluated for successful in vitro drugs adsorption of four drugs, terazosine, telmisartan, glimpiride and rosuvastatin. TGA and PXRD spectra of all these materials in pure form and after drugs adsorption have also been recorded to elaborate the phenomenon of in vitro drugs adsorption in these materials. The amounts of adsorbed drugs and their slow release from all these materials have been monitored by the high performance liquid chromatography (HPLC).
- nano bio-MOF,
- drugs adsorption,
- TGA,
- PXRD,
- HPLC
Citation: Tabinda Sattar, Muhammad Athar. Nano bio-MOFs: Showing drugs storage property among their multifunctional properties[J]. AIMS Materials Science, 2018, 5(3): 508-518. doi: 10.3934/matersci.2018.3.508

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Abstract

Nano bio-MOF compounds 6–8 (cobalt argeninate, cobalt asparaginate, and cobalt glutaminate) have been evaluated for successful in vitro drugs adsorption of four drugs, terazosine, telmisartan, glimpiride and rosuvastatin. TGA and PXRD spectra of all these materials in pure form and after drugs adsorption have also been recorded to elaborate the phenomenon of in vitro drugs adsorption in these materials. The amounts of adsorbed drugs and their slow release from all these materials have been monitored by the high performance liquid chromatography (HPLC).

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