Protein based devices for oral tissue repair and regeneration

Iriczalli Cruz-Maya; Vincenzo Guarino; Marco Antonio Alvarez-Perez; Iriczalli Cruz-Maya; Vincenzo Guarino; Marco Antonio Alvarez-Perez

doi:10.3934/matersci.2018.2.156

AIMS Materials Science

2018, Volume 5, Issue 2: 156-170. doi: 10.3934/matersci.2018.2.156

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Review Topical Sections

Protein based devices for oral tissue repair and regeneration

1.
Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, Italy
2.
Tissue Bioengineering Laboratory, DEPeI-FO, Universidad Nacional Autónoma de México, México

Received: 18 December 2017 Accepted: 24 February 2018 Published: 06 March 2018

In the last decades, a goal of tissue engineering has been devoted to the design of devices with multiple micro- or nano-structures and loaded with bioactive molecules, to mimic the extracellular matrix (ECM) so generating a conducive microenvironment for new tissue replacement/regeneration. The ECM, naturally, is composed of fibrous proteins which provide structural support for tissues, mainly regulating cells behavior in terms of proliferation, growth, survival, shape, migration and differentiation by cell-matrix interactions. Several studies have been just investigated the fabrication of different platforms for the regeneration of teeth, oral mucosa, salivary glands, bone, and periodontium. In this context, many proteins—from a natural or biological source—have been used as instructive substances to in vitro guide tissue organization and functions. In particular, new advances in the definition of protein-based formulations currently represent a great challenge to promote a more effective regeneration of dental tissues to be transplanted into patients to replace damaged, diseased or missing tissues. Hence, the purpose of this review is to discuss the use of protein-based systems for the regeneration of oral tissues.
- structural proteins,
- instructive biomaterials,
- cell materials interactions,
- bioactivity,
- oral tissue engineering
Citation: Iriczalli Cruz-Maya, Vincenzo Guarino, Marco Antonio Alvarez-Perez. Protein based devices for oral tissue repair and regeneration[J]. AIMS Materials Science, 2018, 5(2): 156-170. doi: 10.3934/matersci.2018.2.156

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Abstract

In the last decades, a goal of tissue engineering has been devoted to the design of devices with multiple micro- or nano-structures and loaded with bioactive molecules, to mimic the extracellular matrix (ECM) so generating a conducive microenvironment for new tissue replacement/regeneration. The ECM, naturally, is composed of fibrous proteins which provide structural support for tissues, mainly regulating cells behavior in terms of proliferation, growth, survival, shape, migration and differentiation by cell-matrix interactions. Several studies have been just investigated the fabrication of different platforms for the regeneration of teeth, oral mucosa, salivary glands, bone, and periodontium. In this context, many proteins—from a natural or biological source—have been used as instructive substances to in vitro guide tissue organization and functions. In particular, new advances in the definition of protein-based formulations currently represent a great challenge to promote a more effective regeneration of dental tissues to be transplanted into patients to replace damaged, diseased or missing tissues. Hence, the purpose of this review is to discuss the use of protein-based systems for the regeneration of oral tissues.

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