Cyclodextrin-containing layer-by-layer films and microcapsules: Synthesis and applications

Uichi Akiba; Jun-ichi Anzai; Uichi Akiba; Jun-ichi Anzai

doi:10.3934/matersci.2017.4.832

AIMS Materials Science

2017, Volume 4, Issue 4: 832-846. doi: 10.3934/matersci.2017.4.832

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Cyclodextrin-containing layer-by-layer films and microcapsules: Synthesis and applications

Uichi Akiba ¹,
Jun-ichi Anzai ^{2
,
,}

1.
Graduate School of Engineering and Science, Akita University, 1-1 Tegatagakuen-machi, Akita 010-8502, Japan
2.
Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Sendai 980-8578, Japan

Received: 31 May 2017 Accepted: 16 July 2017 Published: 19 July 2017

This article reviews the synthesis and applications of cyclodextrin (CD)-containing layer-by-layer (LbL) films and microcapsules. CD-containing LbL films and microcapsules have been synthesized through the electrostatic interactions between charged CDs and polyelectrolytes or the formation of host–guest complexes. In the former strategy, sulfonated and carboxylated CDs are often combined with oppositely charged polyelectrolytes. In contrast, in the latter strategy, CD-bearing polymers and guest-modified polymers are used as components of LbL assembly. Typical guest molecules include adamantane, ferrocene, and azobenzene derivatives. Electrochemical biosensors have been constructed by coating the surface of electrodes with CD-containing LbL films. In addition, CD-containing LbL assemblies are used as scaffolds for constructing drug delivery systems, in which hydrophobic, poorly soluble drugs are loaded on the film through host–guest complexation.
- layer-by-layer,
- thin film,
- microcapsule,
- cyclodextrin,
- biosensor,
- drug delivery system
Citation: Uichi Akiba, Jun-ichi Anzai. Cyclodextrin-containing layer-by-layer films and microcapsules: Synthesis and applications[J]. AIMS Materials Science, 2017, 4(4): 832-846. doi: 10.3934/matersci.2017.4.832

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Abstract

This article reviews the synthesis and applications of cyclodextrin (CD)-containing layer-by-layer (LbL) films and microcapsules. CD-containing LbL films and microcapsules have been synthesized through the electrostatic interactions between charged CDs and polyelectrolytes or the formation of host–guest complexes. In the former strategy, sulfonated and carboxylated CDs are often combined with oppositely charged polyelectrolytes. In contrast, in the latter strategy, CD-bearing polymers and guest-modified polymers are used as components of LbL assembly. Typical guest molecules include adamantane, ferrocene, and azobenzene derivatives. Electrochemical biosensors have been constructed by coating the surface of electrodes with CD-containing LbL films. In addition, CD-containing LbL assemblies are used as scaffolds for constructing drug delivery systems, in which hydrophobic, poorly soluble drugs are loaded on the film through host–guest complexation.

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