Perspectives on nanofiber dressings for the localized delivery of botanical remedies in wound healing

Sukhwinder K. Bhullar; Harpal S. Buttar; Sukhwinder K. Bhullar; Harpal S. Buttar

doi:10.3934/matersci.2017.2.370

AIMS Materials Science

2017, Volume 4, Issue 2: 370-382. doi: 10.3934/matersci.2017.2.370

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Perspectives on nanofiber dressings for the localized delivery of botanical remedies in wound healing

Sukhwinder K. Bhullar ^{1,2
,
,},
Harpal S. Buttar ³

1.
Department of Mechanical Engineering, Bursa Technical University, Bursa, Turkey
2.
Department of Mechanical Engineering, University of Victoria, Victoria, B.C., Canada
3.
Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada

Received: 14 November 2016 Accepted: 24 January 2017 Published: 21 February 2017

Based on their antiseptic and anti-inflammatory properties, plant-derived remedies and herbal products have been used since ancient times for wound and burn cure as well as for treating chronic skin diseases like dermatitis and eczema. Biocompatible and biodegradable polymer nanofiber devices are currently fabricated using sophisticated engineering techniques. Such nanofiber structures have proven efficacious for the localized delivery of therapeutic agents for the treatment of wounds due to their unique physical-chemical properties such as large surface-area-to-volume ratio, high porosity, improved cell adherence, cellular proliferation and migration, as well as controlled in vivo biodegradation rates. The remit of this communication is to highlight the methodology used for the fabrication of nanofiber mats and dressings for the localised delivery of herbal products and plant-derived ingredients for wound healing.
- fabrication of nanofiber dressings,
- biodegradable dressings and mats,
- localised delivery of botanical remedies,
- wound healing
Citation: Sukhwinder K. Bhullar, Harpal S. Buttar. Perspectives on nanofiber dressings for the localized delivery of botanical remedies in wound healing[J]. AIMS Materials Science, 2017, 4(2): 370-382. doi: 10.3934/matersci.2017.2.370

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Abstract

Based on their antiseptic and anti-inflammatory properties, plant-derived remedies and herbal products have been used since ancient times for wound and burn cure as well as for treating chronic skin diseases like dermatitis and eczema. Biocompatible and biodegradable polymer nanofiber devices are currently fabricated using sophisticated engineering techniques. Such nanofiber structures have proven efficacious for the localized delivery of therapeutic agents for the treatment of wounds due to their unique physical-chemical properties such as large surface-area-to-volume ratio, high porosity, improved cell adherence, cellular proliferation and migration, as well as controlled in vivo biodegradation rates. The remit of this communication is to highlight the methodology used for the fabrication of nanofiber mats and dressings for the localised delivery of herbal products and plant-derived ingredients for wound healing.

References

[1]	Chirayil C, Mathew L, Thomas S (2014) Review of recent research in nano cellulose preparation from different lignocellulosic fibers. Rev Adv Mater Sci 37: 20–28.
[2]	Zhang L, Webster T (2009) Nanotechnology and nanomaterials: promises for improved tissue regeneration. Nano Today 4: 66–80. doi: 10.1016/j.nantod.2008.10.014
[3]	Sill TJ, von Recum HA (2008) Electrospinning: Applications in drug delivery and tissue engineering. Biomaterials 29: 1989–2006. doi: 10.1016/j.biomaterials.2008.01.011
[4]	Li WJ, Laurencin CT, Caterson EJ, et al. (2002) Electrospun nanofibrous structure: A novel scaffold for tissue engineering. J Biomed Mater Res A 60: 613–621. doi: 10.1002/jbm.10167
[5]	Zahedi P, Rezaeian I, Ranaei‐Siadat SO, et al. (2010) A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages. Polym Advan Technol 21: 77–95.
[6]	Harcup JW, Saul PA (1986) A Study of The Effect of Cadexomer Iodine in The Treatment of Venous Leg Ulcers. Br J Clin Pract 40: 360–364.
[7]	Harding KG, Jones V, Price P (2000) Topical treatment: which dressing to choose. Diabetes Metab Res Rev 16: S47–S50.
[8]	Kittler S, Greulich C, Diendorf J, et al. (2010) Toxicity of silver nanoparticles increases during storage because of slow dissolution under release of silver ions. Chem Mater 22: 4548–4554. doi: 10.1021/cm100023p
[9]	Ormiston MC, Seymour MT, Venn GE, et al. (1985) Controlled Trial of Iodosorb in Chronic Venous Ulcers. Br Med J (Clin Res Ed) 291: 308–310. doi: 10.1136/bmj.291.6491.308
[10]	Percival SL, Bowler PG, Russell D (2005) Bacterial resistance to silver in wound care. J Hosp Infect 40: 1–7.
[11]	Nguyen DT, Orgill DP, Murphy GF (2009) The Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration. In: Orgill DP, Blanco C, Biomaterials For Treating Skin Loss, Woodhead Publishing (UK/Europe) & CRC Press (US), Cambridge/Boca Raton, 25–57.
[12]	Powell HM, Supp DM, Boyce ST (2008) Influence of electrospun collagen on wound contraction of engineered skin substitutes. Biomaterials 29: 834–843. doi: 10.1016/j.biomaterials.2007.10.036
[13]	Wound Care Market by Product (Advanced (Foam, Alginate, NPWT, Active), Surgical, Traditional), Wound Type (Chronic (DFU, Pressure Ulcer), Acute (Burn)), End User (Hospital (Inpatient, Outpatient), Long-Term Care, Home Healthcare)-Global Forecast to 2021, 2016. Available from: http://www.marketsandmarkets.com/PressReleases/wound-care.asp.
[14]	Lu X, Wang C, Wei Y (2009) One-Dimensional Composite Nanomaterials: Synthesis by Electrospinning and Their Applications. Small 5: 2349–2370. doi: 10.1002/smll.200900445
[15]	Boland ED, Wnek GE, Simpson DG, et al. (2001) Tailoring Tissue Engineering Scaffolds Using Electrostatic Processing Techniques: A Study of Poly(Glycolic Acid) Electrospinning. J Macromol Sci A 38: 1231–1243. doi: 10.1081/MA-100108380
[16]	Khil MS, Cha DI, Kim HY, et al. (2003) Electrospun Nanofibrous Polyurethane Membrane as Wound Dressing. J Biomed Mater Res B 67: 675–679.
[17]	Duan Y, Jia J, Wang S, et al. (2007) Preparation of antimicrobial poly(γ-caprolactone) electrospun nanofibers containing silver-loaded zirconium phosphate nanoparticles. J Appl Polym Sci 106: 1208–1214. doi: 10.1002/app.26786
[18]	Kriegel C, Kit KM, McClements DJ, et al. (2009) Electrospinning of chitosan-poly(ethylene oxide) blend nanofibers in the presence of micellar surfactant solutions. Polymer 50: 189–200. doi: 10.1016/j.polymer.2008.09.041
[19]	Au HT, Pham LN, Vu THT, et al. (2012) Fabrication of an antibacterial non-woven mat of a poly(lactic acid)/chitosan blend by electrospinning. Macromol Res 20: 51–58. doi: 10.1007/s13233-012-0010-9
[20]	Van der Schueren L, Steyaert I, De Schoenmaker B, et al. (2012) Polycaprolactone/chitosan blend nanofibres electrospun from an acetic acid/formic acid solvent system. Carbohyd Polym 88: 1221–1226. doi: 10.1016/j.carbpol.2012.01.085
[21]	Sundaramurthi D, Vasanthan KS, Kuppan P, et al. (2012) Electrospun nanostructured chitosan-poly(vinyl alcohol) scaffolds: a biomimetic extracellular matrix as dermal substitute. Biomed Mater 7: 045005. doi: 10.1088/1748-6041/7/4/045005
[22]	Chen JP, Chang GY, Chen JK (2008) Electrospun collagen/chitosan nanofibrous membrane as wound dressing. Colloid Surface A 313: 183–188.
[23]	Dhandayuthapani B, Krishnan UM, Sethuraman S (2010) Fabrication and characterization of chitosan-gelatin blend nanofibers for skin tissue engineering. J Biomed Mater Res B 94: 264–272.
[24]	Cai Z, Mo X, Zhang K, et al. (2010) Fabrication of Chitosan/Silk Fibroin Composite Nanofibers for Wound-dressing Applications. Int J Mol Sci 11: 3529–3539. doi: 10.3390/ijms11093529
[25]	Wang R, Wang Z, Lin S, et al. (2015) Green fabrication of antibacterial polymer/silver nanoparticle nanohybrids by dual-spinneret electrospinning. RSC Adv 5: 40141–40147. doi: 10.1039/C5RA03288A
[26]	Zhao R, Li X, Sun B, et al. (2014) Electrospun chitosan/sericin composite nanofibers with antibacterialproperty as potential wound dressings. Int J Biol Macromol 68: 92–97. doi: 10.1016/j.ijbiomac.2014.04.029
[27]	Gupta RC (2016) Nutraceuticals: Efficacy, Safety and Toxicity.
[28]	Habibi Y, Lucia LA, Rojas OJ (2010) Cellulose nanocrystals: Chemistry, selfassembly, and applications. Chem Rev 110: 3479–3500. doi: 10.1021/cr900339w
[29]	Siro I, Plackett D (2010) Microfibrillated cellulose and new nanocomposite materials: a review. Cellulose 17:459–494.
[30]	Visakh PM, Thomas S (2010) Preparation of Bionanomaterials and their Polymer Nanocomposites. Waste Biomass Valouri 1: 121–134. doi: 10.1007/s12649-010-9009-7
[31]	Klemm D, Heublein B, Fink HP, et al. (2005) Cellulose: Fascinating biopolymer and sustainable raw material. Angew Chem Int Edit 44: 3358–3393. doi: 10.1002/anie.200460587
[32]	Suganya S, Senthil Ram T, Lakshmi BS, et al. (2011) Herbal Drug Incorporated Antibacterial Nanofibrous Mat Fabricated by Electrospinning: An Excellent Matrix For Wound Dressings. J Appl Polym Sci 121: 2893–2899. doi: 10.1002/app.33915
[33]	Sikareepaisan P, Suksamrarn A, Supaphol P (2008) Electrospun gelatin fiber mats containing a herbal-Centellaasiatica-extract and release characteristic of asiaticoside. Nanotechnology 19: 015102. doi: 10.1088/0957-4484/19/01/015102
[34]	Han J, Zhang HT, Zhu LM, et al. (2009) Electrospun biodegradable nanofiber mats for controlled release of herbal medicine. 3^rd International Conference on Bioinformatics and Biomedical Engineering.
[35]	Agnes Mary S, Giri Dev VR (2015) Electrospun herbal nanofibrous wound dressings for skin tissue engineering. J Text I 106: 886–895. doi: 10.1080/00405000.2014.951247
[36]	DeMario MD, Ratain MJ (1998) Oral chemotherapy: rationale and future directions. J Clin Oncol 16: 2557–2567.
[37]	Schneider A, Wang XY, Kaplan DL, et al. (2009) Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing. Acta Biomater 5: 2570–2578. doi: 10.1016/j.actbio.2008.12.013
[38]	Gil ES, Panilaitis B, Bellas E, et al. (2013) Functionalized silk biomaterials for wound healing. Adv Healthc Mater 2: 206–217. doi: 10.1002/adhm.201200192
[39]	Navone SE, Pascucci L, Dossena M, et al. (2014) Decellularized silk fibroin scaffold primed with adipose mesenchymal stromal cells improves wound healing in diabetic mice. Stem Cell Res Ther 5: 7–17. doi: 10.1186/scrt396
[40]	Kshirsagar AY, Vekariya MA, Gupta V, et al. (2015) A Comparative Study of Colostrum Dressing Versus Conventional Dressing in Deep Wounds. J Clin Diagn Res 9: PC01–PC04.
[41]	Borges AC, Eyholzer C, Duc F, et al. (2011) Nanofibrillated cellulose composite hydrogel for the replacement of the nucleus pulposus. Acta Biomater 7: 3412–3421. doi: 10.1016/j.actbio.2011.05.029
[42]	Mathew AP, Oksman K, Pierron D, et al. (2011) Crosslinked fibrous composites based on cellulose nanofibers and collagen with in situ pH induced fibrillation. Cellulose 19: 139–150.
[43]	Valo H, Arola S, Laaksonen P, et al. (2013) Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels. Eur J Pharm Sci 50: 69–77. doi: 10.1016/j.ejps.2013.02.023
[44]	Laurén P, Lou YR, Raki M, et al. (2014) Technetium-99 mlabeled nanofibrillar cellulose hydrogel for in vivo drug release. Eur J Pharm Sci 65: 79–88. doi: 10.1016/j.ejps.2014.09.013
[45]	Sakai K, Kobayashi Y, Saito T, et al. (2016) Partitioned airs at microscale and nanoscale: thermal diffusivity in ultrahigh porosity solids of nanocellulose. Sci Rep 6: 20434. doi: 10.1038/srep20434
[46]	Mertaniemi H, Escobedo-Lucea C, Sanz-Garcia A, et al. (2016) Human stem cell decorated nanocellulose threads for biomedical applications. Biomaterials 82: 208–220. doi: 10.1016/j.biomaterials.2015.12.020
[47]	Chang C, Zhang L (2011) Cellulose-based hydrogels: present status and application prospects. Carbohydr Polym 84: 40–53. doi: 10.1016/j.carbpol.2010.12.023
[48]	El-Newehy MH, Al-Deyab SS, Kenawy ER, et al. (2011) Nanospider Technology for the Production of Nylon-6 Nanofibers for Biomedical Applications. J Nanomater 2011.
[49]	Zhang S, Shim WS, Kim J (2009) Design of ultra-fine nonwovens via electrospinning of Nylon 6: spinning parameters and filtration efficiency. Mater Design 30: 3659–3666. doi: 10.1016/j.matdes.2009.02.017
[50]	Pedicini A, Farris RJ (2004) Thermally induced color change in electrospun fiber mats. J Polym Sci Pol Phys 42: 752–757.
[51]	Deitzel JM, Kosik W, McKnight SH, et al. (2001) Electrospinning of polymer nanofibers with specific surface chemistry. Polymer 43: 1025–1029.
[52]	Nirmala R, Navamathavan R, El-Newehy MH, et al. (2011) Preparation and electrical characterization of polyamide-6/chitosan composite nanofibers via electrospinning. Mater Lett 65: 493–496. doi: 10.1016/j.matlet.2010.10.066
[53]	Zachariades AE, Porter RS, Doshi J, et al. (1995) High modulus polymers. A novel electrospinning process. Polym News 20: 206–207.
[54]	Reneker DH, Yarin AL, Fong H, et al. (2000) Bending instability of electrically charged liquid jets of polymer solutions in Electrospinning. J Appl Phys 87: 4531–4547. doi: 10.1063/1.373532
[55]	Fong H, Reneker DH (1999) Elastomeric nanofibers of styren–butadiene–styrene triblock copolymer. J Polym Sci Polym Phys 37: 3488–3493.
[56]	Teo WE, Ramakrishna S (2006) A Review on Electrospinning Design and Nanofibre Assemblies. Nanotechnology 17: 89–106.
[57]	Wan LS, Wu J, Xu ZK (2006) Porphyrinated Nanofibers via Copolymerization and Electrospinning. Macromol Rapid Comm 27: 1533–1538. doi: 10.1002/marc.200600381
[58]	Wahl DA, Sachlos E, Liu C, et al. (2007) Controlling the processing of collagen hydroxyapatite scaffolds for bone tissue engineering. J Mater Sci-Mater M 18: 201–209.
[59]	Jayakumar R, Prabaharan M, Kumar PTS, et al. (2011) Biomaterials based on chitin and chitosan in wound dressing applications. Biotechnol Adv 29: 322–337. doi: 10.1016/j.biotechadv.2011.01.005
[60]	Hu WW, Yu HN (2013) Co-electrospinning of chitosan/alginate fibers by dual-jet system for modulating material surfaces. Carbohydr Polym 95: 716–727. doi: 10.1016/j.carbpol.2013.02.083
[61]	Lyons J, Ko FK (2004) Nanofibers. Encycl Nanosci Nanotech 6: 727–738.
[62]	Yarin AL, Koombhongse S, Reneker DH (2001) Taylor cone and jetting from liquid droplets in electrospinning of nanofibers. J Appl Phys 90: 4836–4846. doi: 10.1063/1.1408260
[63]	Stanger J, Tucker N, Kirwan K, et al. (2009) Effect of charge density on the Taylor cone in electrospinning. Int J Mod Phys B 23: 1956–1961. doi: 10.1142/S0217979209061895
[64]	Anton F (1938) Method and apparatus for the production of fibers. US Patent 2116942, 1938-5-10.
[65]	Ignatious F, Sun L, Lee CP, et al. (2010) Electrospun nanofibers in oral drug delivery. Pharm Res 27: 576–588. doi: 10.1007/s11095-010-0061-6
[66]	Verreck G, Chun I, Rosenblatt J, et al. (2003) Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble nonbiodegradable polymer. J Control Release 92: 349–360. doi: 10.1016/S0168-3659(03)00342-0
[67]	Ko J, Bhullar SK, Mohtaram NK, et al. (2014) Using mathematical modeling to control topographical properties of poly (ε-caprolactone) melt electrospun scaffolds. J Micromech Microeng 24: 065009. doi: 10.1088/0960-1317/24/6/065009
[68]	Denn MM (1980) Continuous Drawing of Liquids to Form Fibers. Annu Rev Fluid Mech 12: 365–387. doi: 10.1146/annurev.fl.12.010180.002053
[69]	Feng L, Li S, Li H, et al. (2002) Super-Hydrophobic Surface of Aligned Polyacrylonitrile Nanofibers. Angew Chem 141: 1269–1271.
[70]	Ramakrishna S, Fujihara K, Teo W, et al. (2005) An introduction to electrospinning and nanofibers, Singapore: World Scientific Publishing Company.
[71]	Ellison CJ, Phatak A, Giles DW, et al. (2007) Melt blown nanofibers: fiber diameter distributions and onset of fiber breakup. Polymer 48: 3306–3316. doi: 10.1016/j.polymer.2007.04.005
[72]	Grafe T, Graham K (2003) Nanofibers and Nanofiber Webs: A New Class of Nonwovens. Nonwoven Technol Rev 12: 51–55.
[73]	Medeiros ES, Glenn GM, Klamczynski AP, et al. (2009) Solution blow spinning: A new method to produce micro‐and nanofibers from polymer solutions. J Appl Polym Sci 113: 2322–2330. doi: 10.1002/app.30275
[74]	Srinivasan S, Chhatre SS, Mabry JM, et al. (2011) Solution spraying of poly(methyl methacrylate) blends to fabricate microtextured, superoleophobic surfaces. Polymer 52: 3209–3218. doi: 10.1016/j.polymer.2011.05.008
[75]	Behrens AM, Casey BJ, Sikorski MJ, et al. (2014) In situ deposition of PLGA nanofibers via solution blow spinning. ACS Macro Lett 3: 249–254. doi: 10.1021/mz500049x

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