Non-autonomous consequences of cell death and other perks of being metazoan

Tin Tin Su; Tin Tin Su

doi:10.3934/genet.2015.1.54

AIMS Genetics

2015, Volume 2, Issue 1: 54-69. doi: 10.3934/genet.2015.1.54

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Non-autonomous consequences of cell death and other perks of being metazoan

Tin Tin Su ^,

Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309-0347, USA

Received: 10 November 2014 Accepted: 26 January 2015 Published: 05 February 2015

Drosophila melanogaster remains a foremost genetic model to study basic cell biological processes in the context of multi-cellular development. In such context, the behavior of one cell can influence another. Non-autonomous signaling among cells occurs throughout metazoan development and disease, and is too vast to be covered by a single review. I will focus here on non-autonomous signaling events that occur in response to cell death in the larval epithelia and affect the life-death decision of surviving cells. I will summarize the use of Drosophila to study cell death-induced proliferation, apoptosis-induced apoptosis, and apoptosis-induced survival signaling. Key insights from Drosophila will be discussed in the context of analogous processes in mammalian development and cancer biology.
- Drosophila,
- imaginal discs,
- apoptosis,
- caspase,
- cancer
Citation: Tin Tin Su. Non-autonomous consequences of cell death and other perks of being metazoan[J]. AIMS Genetics, 2015, 2(1): 54-69. doi: 10.3934/genet.2015.1.54

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Abstract

Drosophila melanogaster remains a foremost genetic model to study basic cell biological processes in the context of multi-cellular development. In such context, the behavior of one cell can influence another. Non-autonomous signaling among cells occurs throughout metazoan development and disease, and is too vast to be covered by a single review. I will focus here on non-autonomous signaling events that occur in response to cell death in the larval epithelia and affect the life-death decision of surviving cells. I will summarize the use of Drosophila to study cell death-induced proliferation, apoptosis-induced apoptosis, and apoptosis-induced survival signaling. Key insights from Drosophila will be discussed in the context of analogous processes in mammalian development and cancer biology.

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