Supplementary Table S3. Hub genes in the protein-protein interaction network of the differentially-expressed genes between colon tumor endothelial cells versus colon normal endothelial cells.		
		
Gene symbol	Degree of interaction	Betweenness
FN1	65	1825.83
GAPDH	58	1191.26
HSP90B1	42	899.68
COL1A1	39	315.57
CTNNB1	32	879.1
PDIA6	32	475.67
COL1A2	32	344.19
LAMB1	31	110.91
LAMC1	29	101.68
SPARC	27	114.06
ITGA4	25	87.48
IGFBP3	24	110.64
COL4A1	24	66.35
VWF	23	83.58
CYR61	23	10.49
DDOST	22	345.51
CXCL1	22	280.04
COL4A2	22	121.69
COL18A1	21	399.15
ITGA5	21	188.4
SDC1	21	69.71
FSTL1	21	68.34
IGFBP5	21	59.16
CD38	20	273.25
CKAP4	20	134.15
IGFBP7	19	70.03
MMP1	18	232.31
MANF	18	219.69
ITGB7	18	87.23
LAMA4	18	16.74
SELE	17	295.94
CCR2	17	205.26
MET	17	197.97
CCT2	17	109.15
XBP1	17	105.38
TIMP2	17	78.65
SEC61B	17	59.58
SPN	17	58.64
SEC11C	17	41.66
APLP2	17	40.24
PLAU	16	142.22
PRSS23	16	5.35
IGF2	16	0
ACTG1	16	0
CCT3	15	125.41
DNAJB11	15	112.37
OS9	15	71.75
GZMB	15	60.24
CD27	15	57.04
CD79A	15	24.18
COL12A1	15	9.24
TMEM132A	15	0
GNG7	14	254.69
SSR4	14	80.68
SNAI1	14	23.84
SSR3	14	23.23
VWA1	14	0
ABCG2	13	123.7
BGLAP	13	33.82
DERL3	13	17.58
ITGA8	13	5.68
DERL2	13	0
LDLR	13	0
CD48	13	0
SERP1	12	40.39
SEL1L	12	25.52
CXCL2	12	16.58
SPCS2	12	16.23
SPCS3	12	13.35
NES	12	9.7
ERLEC1	12	2.92
SPCS1	12	0
HTRA1	11	231.58
CCT4	11	209.34
YWHAB	11	146.59
HERPUD1	11	10.23
SDF2L1	11	2.99
DNAJB9	11	2.94
NID2	11	0
COL15A1	10	83
CD81	10	80.37
LEF1	10	43
TRAM1	10	15.97
OSTC	10	14.17
MCAM	10	10.37
IGLL5	10	0
CD4	10	0