Supplementary Table S1. Upregulated genes in colon tumor endothelial cells versus colon normal endothelial cells. EntrezID Symbols logFC P.Value adj.P.Val Name 6678 SPARC 2.2095 0.00094931 0.028925 "secreted protein, acidic, cysteine-rich (osteonectin)" 3490 IGFBP7 2.1899 0.00076455 0.026398 insulin-like growth factor binding protein 7 1284 COL4A2 2.1885 0.00018585 0.015676 "collagen, type IV, alpha 2" 6401 SELE 1.9729 0.0017217 0.038413 selectin E 2919 CXCL1 1.8516 0.00026149 0.01751 "chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)" 7450 VWF 1.847 0.0023094 0.044246 von Willebrand factor 83643 CCDC3 1.8241 0.00035695 0.019461 coiled-coil domain containing 3 11167 FSTL1 1.6843 0.00047855 0.021752 follistatin-like 1 64856 VWA1 1.6167 0.00019054 0.015826 von Willebrand factor A domain containing 1 10410 IFITM3 1.5925 0.00030573 0.01843 interferon induced transmembrane protein 3 4256 MGP 1.581 0.0013182 0.033353 matrix Gla protein 5420 PODXL 1.5804 0.0015054 0.035996 podocalyxin-like 10537 UBD 1.5465 0.00015819 0.015196 ubiquitin D 79630 C1orf54 1.4897 0.0019397 0.040471 chromosome 1 open reading frame 54 3486 IGFBP3 1.4797 0.0000293 0.0080687 insulin-like growth factor binding protein 3 3002 GZMB 1.4727 0.001818 0.039417 "granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)" 3481 IGF2 1.464 0.0025105 0.046033 insulin-like growth factor 2 (somatomedin A) 2920 CXCL2 1.412 0.0018425 0.039558 chemokine (C-X-C motif) ligand 2 10581 IFITM2 1.3905 0.0017501 0.03874 interferon induced transmembrane protein 2 (1-8D) 358 AQP1 1.3491 0.0014246 0.034774 aquaporin 1 (Colton blood group) 4162 MCAM 1.3465 0.00036697 0.019461 melanoma cell adhesion molecule 4017 LOXL2 1.2644 0.00038906 0.020157 lysyl oxidase-like 2 2887 GRB10 1.2577 0.000879 0.028017 growth factor receptor-bound protein 10 5654 HTRA1 1.2286 0.00036481 0.019461 HtrA serine peptidase 1 5031 P2RY6 1.2278 0.0020469 0.041456 "pyrimidinergic receptor P2Y, G-protein coupled, 6" 80781 COL18A1 1.2039 0.00014407 0.014618 "collagen, type XVIII, alpha 1" 340198 IFITM4P 1.1723 0.001893 0.039918 interferon induced transmembrane protein 4 pseudogene 2335 FN1 1.1483 0.0003951 0.020318 fibronectin 1 3678 ITGA5 1.1376 0.00029592 0.018375 "integrin, alpha 5 (fibronectin receptor, alpha polypeptide)" 3491 CYR61 1.1231 0.0028383 0.04934 "cysteine-rich, angiogenic inducer, 61" 2069 EREG 1.1202 0.001054 0.030446 epiregulin 1282 COL4A1 1.1015 0.00026203 0.01751 "collagen, type IV, alpha 1" 3912 LAMB1 1.1009 0.00044865 0.021038 "laminin, beta 1" 1306 COL15A1 1.0877 0.0019768 0.040935 "collagen, type XV, alpha 1" 11098 PRSS23 1.0731 0.0010013 0.02947 "protease, serine, 23" 4312 MMP1 1.0684 0.0000141 0.0075042 matrix metallopeptidase 1 (interstitial collagenase) 1277 COL1A1 1.0629 0.0020595 0.041488 "collagen, type I, alpha 1" 1466 CSRP2 1.0598 0.0011592 0.031362 cysteine and glycine-rich protein 2 27253 PCDH17 1.0397 0.00059656 0.02385 protocadherin 17 5328 PLAU 1.0347 0.00026687 0.017523 "plasminogen activator, urokinase" 1278 COL1A2 1.0154 0.0012843 0.032948 "collagen, type I, alpha 2" 1012 CDH13 1.0133 0.0017516 0.03874 "cadherin 13, H-cadherin (heart)" 9308 CD83 0.98934 0.0000558 0.0093929 CD83 molecule 9235 IL32 0.97985 0.000022 0.0080687 interleukin 32 8870 IER3 0.97588 0.00029076 0.018282 immediate early response 3 11096 ADAMTS5 0.96865 0.0014153 0.034651 "ADAM metallopeptidase with thrombospondin type 1 motif, 5" 23213 SULF1 0.96477 0.0019748 0.040935 sulfatase 1 3488 IGFBP5 0.95444 0.0019143 0.040306 insulin-like growth factor binding protein 5 8862 APLN 0.94042 0.00052565 0.022512 apelin 112464 PRKCDBP 0.93022 0.0020145 0.041162 "protein kinase C, delta binding protein" 6303 SAT1 0.91799 0.00013058 0.014223 spermidine/spermine N1-acetyltransferase 1 6415 SEPW1 0.91532 0.00051201 0.02228 "selenoprotein W, 1" 4050 LTB 0.88998 0.0018807 0.039779 "lymphotoxin beta (TNF superfamily, member 3)" 5478 PPIA 0.88447 0.001074 0.030446 peptidylprolyl isomerase A (cyclophilin A) 54972 TMEM132A 0.88362 0.0000373 0.0084608 transmembrane protein 132A 22795 NID2 0.87033 0.0000362 0.0084248 nidogen 2 (osteonidogen) 55466 DNAJA4 0.86539 0.0017917 0.039092 "DnaJ (Hsp40) homolog, subfamily A, member 4" 57124 CD248 0.86227 0.0021719 0.042981 "CD248 molecule, endosialin" 6615 SNAI1 0.86049 0.00013821 0.014594 snail homolog 1 (Drosophila) 1434 CSE1L 0.85298 0.00031577 0.01843 CSE1 chromosome segregation 1-like (yeast) 975 CD81 0.85038 0.0021441 0.042613 CD81 molecule 7529 YWHAB 0.84641 0.00042505 0.020903 "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide" 164022 PPIAL4A 0.83999 0.0021114 0.042267 peptidylprolyl isomerase A (cyclophilin A)-like 4A 6282 S100A11 0.82893 0.00050663 0.02228 S100 calcium binding protein A11 483 ATP1B3 0.82296 0.00083854 0.027422 "ATPase, Na+/K+ transporting, beta 3 polypeptide" 3945 LDHB 0.80683 0.00022866 0.016748 lactate dehydrogenase B 1499 CTNNB1 0.79793 0.00000383 0.0075042 "catenin (cadherin-associated protein), beta 1, 88kDa" 5796 PTPRK 0.79198 0.0018229 0.039461 "protein tyrosine phosphatase, receptor type, K" 11082 ESM1 0.78854 0.00094554 0.028925 endothelial cell-specific molecule 1 163732 CITED4 0.7883 0.0000141 0.0075042 "Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4" 147495 APCDD1 0.78129 0.0025073 0.046033 adenomatosis polyposis coli down-regulated 1 10576 CCT2 0.78017 0.00033525 0.019006 "chaperonin containing TCP1, subunit 2 (beta)" 3759 KCNJ2 0.76861 0.00020705 0.016367 "potassium inwardly-rectifying channel, subfamily J, member 2" 6659 SOX4 0.76703 0.000049 0.0089675 SRY (sex determining region Y)-box 4 3915 LAMC1 0.76637 0.0011715 0.031443 "laminin, gamma 1 (formerly LAMB2)" 55959 SULF2 0.76303 0.0010651 0.030446 sulfatase 2 10575 CCT4 0.76133 0.0000483 0.0089675 "chaperonin containing TCP1, subunit 4 (delta)" 23621 BACE1 0.75371 0.00036258 0.019461 beta-site APP-cleaving enzyme 1 51330 TNFRSF12A 0.73811 0.0014003 0.034625 "tumor necrosis factor receptor superfamily, member 12A" 4860 PNP 0.73676 0.00024893 0.017132 purine nucleoside phosphorylase 10763 NES 0.73405 0.0011824 0.031608 nestin 2597 GAPDH 0.73154 0.0000742 0.010373 glyceraldehyde-3-phosphate dehydrogenase 7203 CCT3 0.72024 0.0000199 0.0080687 "chaperonin containing TCP1, subunit 3 (gamma)" 8663 EIF3C 0.71894 0.00021647 0.016636 "eukaryotic translation initiation factor 3, subunit C" 55353 LAPTM4B 0.71633 0.0020087 0.041105 lysosomal protein transmembrane 4 beta 3728 JUP 0.71401 0.00087618 0.028006 junction plakoglobin 10376 TUBA1B 0.71168 0.00059809 0.02385 "tubulin, alpha 1b" 6004 RGS16 0.70969 0.0015364 0.036288 regulator of G-protein signaling 16 71 ACTG1 0.70374 0.00054725 0.023112 "actin, gamma 1" 4233 MET 0.6997 0.00063782 0.024591 met proto-oncogene (hepatocyte growth factor receptor) 3910 LAMA4 0.69833 0.00044827 0.021038 "laminin, alpha 4" 1947 EFNB1 0.69793 0.00034809 0.019283 ephrin-B1 3930 LBR 0.69793 0.0015274 0.036203 lamin B receptor 10769 PLK2 0.6832 0.00077045 0.026512 polo-like kinase 2 6709 SPTAN1 0.6823 0.00000636 0.0075042 "spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)" 59338 PLEKHA1 0.67508 0.00097145 0.029122 "pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1" 2191 FAP 0.67243 0.0027127 0.048671 "fibroblast activation protein, alpha" 334 APLP2 0.67088 0.0000725 0.010346 amyloid beta (A4) precursor-like protein 2 10381 TUBB3 0.66858 0.0000285 0.0080687 "tubulin, beta 3 class III" 7837 PXDN 0.66187 0.0019931 0.041027 peroxidasin homolog (Drosophila) 5782 PTPN12 0.64676 0.0025093 0.046033 "protein tyrosine phosphatase, non-receptor type 12" 3838 KPNA2 0.64281 0.0000497 0.0089675 "karyopherin alpha 2 (RAG cohort 1, importin alpha 1)" 57608 KIAA1462 0.64276 0.0011729 0.031443 KIAA1462 84448 ABLIM2 0.64201 0.0016656 0.037732 "actin binding LIM protein family, member 2" 2091 FBL 0.64112 0.00055886 0.023215 fibrillarin 196 AHR 0.64082 0.00030245 0.01843 aryl hydrocarbon receptor 440915 POTEKP 0.63929 0.0000429 0.0088644 "POTE ankyrin domain family, member K, pseudogene" 51176 LEF1 0.63478 0.00078908 0.026798 lymphoid enhancer-binding factor 1 9315 NREP 0.63376 0.00031263 0.01843 neuronal regeneration related protein homolog (rat) 1303 COL12A1 0.62345 0.00000351 0.0075042 "collagen, type XII, alpha 1" 9531 BAG3 0.61866 0.0019234 0.040373 BCL2-associated athanogene 3 3949 LDLR 0.60128 0.00013926 0.014594 low density lipoprotein receptor 7086 TKT 0.59944 0.0021375 0.042545 transketolase 22846 VASH1 0.59896 0.0016266 0.037301 vasohibin 1 11328 FKBP9 0.59618 0.00094091 0.028924 "FK506 binding protein 9, 63 kDa" 644936 LOC644936 0.59188 0.00014477 0.014618 "actin, beta pseudogene" 4172 MCM3 0.58799 0.0010718 0.030446 minichromosome maintenance complex component 3